PhD Position
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PhD-Position: Investigating peptide-lipid interactions using biophysical techniques and bioassays An interdisciplinary approach to solving endotoxin related problems in the pharmaceutical industry Would you like to work with pharmaceutically relevant peptides in a collaboration between University of Copenhagen and Novo Nordisk A/S? And would you like to help Novo Nordisk improve analytical workflows by developing new assays? Then apply now for the PhD position!
The position Novo Nordisk A/S is offering a three-year industrial PhD position in collaboration with Department of Pharmacy at University of Copenhagen. The project will focus on developing analytical tools to study how pharmaceutically relevant peptides interact with bacterial endotoxin to form peptide-endotoxin complexes. The goal is to unravel the underlaying pathways and understand how pharmaceutical excipient either increase or decrease the complexation propensity and, importantly, reverse the association. You will be trained in different versions of the limulus amebocyte lysate (LAL) assay, which is the bioassay the project is focused on optimising. To do so, you will be applying a vast battery of biophysical techniques (e.g. NMR, SAXS/DLS and FIDA) and you will investigate how both various physical stress conditions (e.g. heating/freezing, sonication, shaking) and excipients (e.g. detergents, salts, acid/base) affect the peptide-endotoxin equilibria. Qualifications As an applicant you must have: Obtained a Master´s degree in biophysics, (bio-)chemistry, pharmaceutical s ciences or related areas prior to the starting date Fluency in English and excellent communication skills Interest in working at the interface between different scientific disciplines Danish working permit
It will help your application if you have experience with one or more of the subjects below Experience with biophysical techniques such as NMR , DSC , DLS , FIDA or ITC Experience with studying protein structure and/or interactions Experience with ELISA or with similar bioassays Experience with data analysis in Python or Matlab Application procedure The application, in English, must be submitted electronically by clicking APPLY NOW below. Your application must include: Cover letter: Letter stating the interest in and qualifications for the project (max. one page) Full CV Diploma and transcripts of records: Master´s degree diploma (including grade transcripts). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used It may help your application to furthermore include: A publication list A recommendation letter Contact Professor Jesper Østergaard, Department of Pharmacy, Email: jesper.ø[email protected], tel. +45 35336138). Novo Nordisk Specialist René Bech Ørving Email: [email protected] direct phone: +45 30 796500 Novo Nordisk A/S co- supervisor s : Sr. Research Scientist Malthe Schack Email: [email protected] direct phone: +45 30796510 Sr. Research Scientist Martin Pedersen Email: [email protected] direct phone: +4530736377 Deadline
15.04.2023.
Please note that only online applications will be accepted. Applications received later than this date will not be considered. Questions? For questions in general about the position: Reach out to Jesper or René For questions regarding the biophysical parts of the project: Reach out to Martin or Malthe Novo Nordisk A/S and The University of Copenhagen commit to an inclusive recruitment process and equality of opportunity for all our applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
The position Novo Nordisk A/S is offering a three-year industrial PhD position in collaboration with Department of Pharmacy at University of Copenhagen. The project will focus on developing analytical tools to study how pharmaceutically relevant peptides interact with bacterial endotoxin to form peptide-endotoxin complexes. The goal is to unravel the underlaying pathways and understand how pharmaceutical excipient either increase or decrease the complexation propensity and, importantly, reverse the association. You will be trained in different versions of the limulus amebocyte lysate (LAL) assay, which is the bioassay the project is focused on optimising. To do so, you will be applying a vast battery of biophysical techniques (e.g. NMR, SAXS/DLS and FIDA) and you will investigate how both various physical stress conditions (e.g. heating/freezing, sonication, shaking) and excipients (e.g. detergents, salts, acid/base) affect the peptide-endotoxin equilibria. Qualifications As an applicant you must have:
It will help your application if you have experience with one or more of the subjects below
15.04.2023.
Please note that only online applications will be accepted. Applications received later than this date will not be considered. Questions? For questions in general about the position: Reach out to Jesper or René For questions regarding the biophysical parts of the project: Reach out to Martin or Malthe Novo Nordisk A/S and The University of Copenhagen commit to an inclusive recruitment process and equality of opportunity for all our applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
Information og data
Denne ledige stilling har jobtypen "Administrativ medarbejder", og befinder sig i kategorien "Kontor, handel og service".
Arbejdsstedet er beliggende i Måløv.
Jobbet er oprettet på vores service den 8.3.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Administrativ medarbejder
- Måløv
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