PhD fellowship in Adhesion G protein-coupled receptor signal transduction
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København N
We are offering a PhD fellowship in adhesion GPCR signal transduction commencing 1 September 2024 or after agreement.
Our group and research
You will join the Mathiasen Group at the Laboratory of Molecular Pharmacology (Molpharm) in the Department of Biomedical Sciences. The Mathiasen group is one of multiple groups at Molpharm studying G protein-coupled receptors (GPCRs). The Laboratory offers a dynamic and social work environment, where students at all levels (BSc, MSc, and PhD), postdocs, technicians and scientists from various cultures work together on a variety of interdisciplinary projects, and you will engage and collaborate with several colleagues in the lab.
In the Mathiasen group we focus on investigating the signaling properties and unexplored biology of Adhesion GPCRs and the implications of this receptor family in human health and disease.
Project description
The project aims to characterize and understand the cellular signaling properties of the adhesion GPCR ADGRL3. ADGRL3 has been implicated in ADHD and other psychiatric disorders that involve dopamine dysfunction, such as schizophrenia. ADGRL3 is expressed in the brain, and is composed of a giant protein structure that both binds ligands across the synapse and controls intracellular signaling. Yet many of ADGRL3 basic functions remain unexplored, and understanding the cellular actions of ADGRL3 is a critical milestone towards future drugdevelopment efforts.
The successful candidate will primarily use a combination of plate-based GPCR signaling assays, biophysical assays and advanced fluorescence microscopy techniques to study ADGRL3. The project will also involve general molecular biology techniques and data analysis of both plate-based and microscopy-based results.
Principal supervisor isAssistant Professor,Signe Mathiasen, Department of Biomedical Sciences, ,61658536[email protected]https://healthsciences.ku.dk/phd/guidelines/https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database.http://employment.ku.dk/faculty/recruitment-process/Jobnet.dk
Our group and research
You will join the Mathiasen Group at the Laboratory of Molecular Pharmacology (Molpharm) in the Department of Biomedical Sciences. The Mathiasen group is one of multiple groups at Molpharm studying G protein-coupled receptors (GPCRs). The Laboratory offers a dynamic and social work environment, where students at all levels (BSc, MSc, and PhD), postdocs, technicians and scientists from various cultures work together on a variety of interdisciplinary projects, and you will engage and collaborate with several colleagues in the lab.
In the Mathiasen group we focus on investigating the signaling properties and unexplored biology of Adhesion GPCRs and the implications of this receptor family in human health and disease.
Project description
The project aims to characterize and understand the cellular signaling properties of the adhesion GPCR ADGRL3. ADGRL3 has been implicated in ADHD and other psychiatric disorders that involve dopamine dysfunction, such as schizophrenia. ADGRL3 is expressed in the brain, and is composed of a giant protein structure that both binds ligands across the synapse and controls intracellular signaling. Yet many of ADGRL3 basic functions remain unexplored, and understanding the cellular actions of ADGRL3 is a critical milestone towards future drugdevelopment efforts.
The successful candidate will primarily use a combination of plate-based GPCR signaling assays, biophysical assays and advanced fluorescence microscopy techniques to study ADGRL3. The project will also involve general molecular biology techniques and data analysis of both plate-based and microscopy-based results.
Principal supervisor isAssistant Professor,Signe Mathiasen, Department of Biomedical Sciences, ,61658536[email protected]https://healthsciences.ku.dk/phd/guidelines/https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database.http://employment.ku.dk/faculty/recruitment-process/Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i København N.
Jobbet er oprettet på vores service den 18.4.2024, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- 30.04.2024
- Øvrige
- København N
- Søndag den 05. maj 2024
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