Senior / Lead Scientist - Computational Protein Design
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Are you enthusiastic about driving the design of next generation biologics that will change the life of patients with diabetes and other serious chronic diseases? Are you an expert in employing computational protein design techniques and have a deep curiosity for modern data science technologies? Do you thrive in an informal working environment? Then apply today! You could be our next ‘Molecular Modelling’ / ‘Computational Protein Design’ Scientist within the ‘Computational Drug Design’ area at Novo Nordisk A/S. About the Position A key part of the role will be to work within the drug development projects in early research and support the development of new drug candidates as well as the initiation of new drug pipeline projects. This requires close collaboration with other research scientists in multidisciplinary teams and solving very ambitious scientific goals. The position also requires close collaboration with our data science and machine learning colleagues across the global sites of the ‘Digital Science & Innovation’ area as well as to contribute to the onboarding and development of new computational drug design methods. For this position, we are looking for someone with experience and interests in de novo design of protein minibinder, and/or protein engineering of enzymes and other biopharmaceutical proteins. Key responsibilities: Apply computational methods to guide the design of biologics, including de novo design of proteins and optimization of biopharmaceutical properties of proteins and enzymes via structure- and ML-based methods Apply predictive models for biologics design, including developability engineering and experimental design of high-throughput variant libraries. Influences the research pipeline by proposing new compound design projects that support the strategic in-house research agenda The ideal candidate has a general curiosity and excellent track record within drug discovery, molecular modelling, and/or machine learning technologies, is able to identify and address key project challenges, can collaborate well within a multidisciplinary environment, has a positive attitude towards challenges, takes the initiative for driving projects, and can stay on top of things in a dynamic working environment. Qualifications A PhD degree within a computational chemistry or biology discipline, such as Computational Protein Design or Molecular Modelling, and 2+ years of drug discovery experience in relevant pharma/biotech R&D environment or comparable track record of post graduate experience in academia. Ph.D. with 8+ years experience for Principal Scientist level and proven track record in relevant scientific field(s) and drug discovery. Proven track record and in-depth knowledge of applying structural modelling for biologics in a drug discovery context, preferably for protein minibinder, enzymes, and other biopharmaceutical proteins. Highly skilled and experienced using protein modelling software such as Rosetta, Schrodinger and/or MOE. Experience within programming and scripting, statistical analysis, machine learning, and cloud computing is considered a plus. Excellent interpersonal skills with an ability to respond to shifting priorities in a dynamic setting, a positive attitude towards challenges, and great communication skills to thrive in a multidisciplinary, collaborative working environment. About the Department The Protein Engineering department is part of Novo Nordisk’s Computational Drug Design (CDD) area where we apply and develop state-of-the-art capabilities in structure-based modelling and AI/ML approaches for drug design. Scientists within CDD collaborate seamlessly with teams across the globe to invent better molecules faster. With an unbiased approach to drug modalities, in-house access to the newest screening techniques, and world-class experimentation, we have a wealth of opportunities to impact our pipeline and ultimately save and improve patient lives. We work in multidisciplinary, highly collaborative discovery teams both locally and across Novo Nordisk’s global network to invent novel medicines by applying advanced computational techniques and developing innovative computational methods. We also engage in external collaborations to ensure access to cutting edge research and technology. The Protein Engineering team is focusing on the design of biopharmaceutical proteins such as protein minibinder and protein replacement therapies, using Molecular Modelling and Machine Learning approaches. We collaborate closely with our experimental colleagues in early research to improve and accelerate the design of new drug candidates. With a team of scientists located in Denmark, United States and potentially also United Kingdom, we strive to deliver the latest advancements in protein therapeutics to benefit patient health and global medicine. Contact For further information, please contact Simone Fulle, Head of Department ([email protected]). We are looking to hire in the following locations: • Copenhagen, Denmark • Seattle, WA or Lexington, MA, US Please note that we will consider different levels of seniority and we will conduct interviews on an ongoing basis. Title and conditions are evaluated based on the individual experience and contribution. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants and so request you to refrain from adding a photo in your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
Information og data
Denne ledige stilling har jobtypen "Forretningsudvikler", og befinder sig i kategorien "Kommunikation, marketing, salg".
Arbejdsstedet er beliggende i Måløv.
Jobbet er oprettet på vores service den 14.4.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
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