2-year Postdoc in Cell Therapies for Type 1 Diabetes
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Do you want to take part in bringing stem cell-based therapies to patients suffering from type 1 diabetes and other serious chronic diseases? We are looking for an enthusiastic postdoc candidate to drive an exciting project and help us solve our challenges in drug product development pipelines together with an outstanding academic collaboration with Dr. Samantha Morris. Apply today and join us! The position In this postdoc position, you will be driving a project called Inferring Lineage and Perturbing Gene Regulatory Networks of Stem Cell to Beta cell differentiation granted by novoSTAR for 2 years, in collaboration with the Morris lab at Washington University in St. Louis. Therefore, you have the opportunity to spend maximum 6 months at Morris lab to gain experience and transfer knowledge. The proposed project aims to improve purity and robustness in pancreatic beta cell differentiation. We plan to use advanced biotechnology and computational methodologies to better understand cell fate decisions and to characterize the key molecular players responsible for this phenomenon. The study will utilize single-cell transcriptomics (scRNA-seq), accessible chromatin profiling (scATAC-seq), lineage tracing (CellTagging) and lineage restriction (precise genome editing) to profile cell identity, reconstruct clonal history and identify key gene regulators of differentiation into pancreatic beta cells. The results of this interdisciplinary approach will contribute to the improvement of the purity and effectiveness of cell therapy products and to the understanding of the mechanisms underlying cell differentiation. As a Postdoc, you will join a dedicated team with extensive experience in Next-generation sequencing (NGS) technologies, beta cell differentiation and suspension culture systems. Some of your day-to-day tasks will include: Leading the study and executing the project with your strong expertise in cutting-edge biotechnological methodologies Working together with senior cell therapy scientists and bioinformatics specialists, under supervision of Dr. Samantha Morris and Cell Therapy research leadership team Collaborating closely with our internal Cell Therapy discovery, Cell Therapy Biology and genome editing team and receiving extensive support from our bioinformatics specialists for data analysis Qualifications You have a PhD in Biological sciences, biotechnology or similar fields plus experience in working with mammalian cell culture. Hands-on experience with human pluripotent stem cells in both adherent and suspension culture will be considered a big advantage. To succeed in this position, you have: Robust experience with Molecular biology methods in addition to scRNA-seq / scATAC-seq library prep and Illumina sequencing Hands-on experience with CRISPR-screening and ideally lineage tracing techniques Preferably experience in NGS data analysis and R/Python programming A “can-do” attitude and strong drive to take responsibility Willingness to travel and gain experience abroad Proficiency in spoken and written English On a personal level, you have a flexible and positive mindset that embraces change with a positive attitude. We highly appreciate good communication and collaboration skills to ensure a high level of knowledge sharing and a good team spirit. Furthermore, you are quality-conscious, well-organised and attentive to details. About the department The Stem Cell Therapy Research Organization is a dynamic, technology driven area, part of Cell Therapy R&D, a Transformational Research Unit (TRU) within Novo Nordisk. The TRU is unique in the sense that it covers the full R&D value chain, which means we function as an integrated unit, spanning from early research to GMP manufacturing and clinical development in the same organization. We consist of different departments in which you will be mostly collaborating with Cell Therapy Discovery, Stem Cell Biology and Cell Engineering. We are based in Novo Nordisk Park in Måløv, Denmark. Working at Novo Nordisk At Novo Nordisk, we don’t wait for change. We drive it. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. From research and development, through to manufacturing, marketing and sales – we’re all working to move the needle on patient care. Contact For further information please contact Atefeh Lafzi, Specialist at [email protected] or +45-34480587 or Nicolaj Christophersen, Director of Cell Therapy Discovery, at [email protected] or +45-30794047. Shortlisted candidates will be co-evaluated together with Dr. Samantha Morris, hence your CV will be shared with Morris lab at Washington University in St. Louis. Deadline 30 January 2024. We will process applications as we receive them, so please do not hesitate to apply. You do not need to attach a cover letter to your application, but please include a few sentences about your motivation to apply in your CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo in your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
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Denne ledige stilling har jobtypen "Forretningsudvikler", og befinder sig i kategorien "Kommunikation, marketing, salg".
Arbejdsstedet er beliggende i Måløv.
Jobbet er oprettet på vores service den 16.1.2024, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
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