PhD Fellowship to Study the Role of Epigenetics in Pancreatic β-cell Maturation and Function
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Odense M
The Mandrup Group, Department of Biochemistry and Molecular Biology invites applications from outstanding candidates who are interested in joining our Islet Team to investigate the role of epigenetic modification in pancreatic β-cell maturation. The position is available from 15 September 2023, or as soon as possible thereafter. Application deadline: 31 July 2023.
Research project and role
The Mandrup Group has a longstanding interest in understanding the transcriptional mechanisms of pancreatic β-cell plasticity. Recently we made some interesting discoveries regarding the role of specific epigenomic modifiers in pancreatic β-cell maturation and function. In a new project, funded by the Novo Nordisk Foundation, we are following up on these findings.
As a PhD fellow on this project, you will be working closely with a postdoc spearheading this project. You will apply a broad range of functional genomics, cellular and physiological technologies to determine the role of these epigenetic modifiers in β-cell maturation, in vivo as well as in vitro. Your work will be a combination of both experimental and computational approaches to address the key questions of the project.
The Mandrup Group
The Mandrup Group has a long-standing interest in understanding the molecular crosstalk between transcriptional regulation and metabolism in adipocytes and pancreatic β-cells and to understand the molecular basis for the plasticity of cells in the adipose tissue and endocrine pancreas. We also have a long-time interest in the transcriptional network regulating lineage determination and differentiation of adipocyte progenitors. Our laboratory combines genome-wide studies of factor binding, epigenetic marks and chromatin structure with detailed molecular analyses of the crosstalk between transcriptional regulators. We run an inhouse sequencing platform including single cell sequencing and bioinformatic pipeline.
Susanne Mandrup is Director of ADIPOSIGN as well as the Center of Excellence in Functional Genomics and Tissue Plasticity, and she heads the Functional Genomics and Metabolism Research Unit.
The research unit currently hosts eight independent research groups focusing on various aspects of functional genomics as it pertains to the regulation of cellular differentiation and metabolism. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging, and transgenic mouse work. Strategic research alliances exist with the Odense University Hospital (OUH).
Qualifications/requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:
We offer:
For further information please contact Professor Susanne Mandrup ([email protected]).
Application, salary etc.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be in English and made in the form of a Declaration of Interest including the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box "Application form")
• Detailed CV, including personal contact information
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades
• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail: [email protected] mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Shortlisting may be used in the assessment process.
Further information about the PhD-study can be found at the homepage of the University.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Further information for international applicants about entering and working in Denmark.
Research project and role
The Mandrup Group has a longstanding interest in understanding the transcriptional mechanisms of pancreatic β-cell plasticity. Recently we made some interesting discoveries regarding the role of specific epigenomic modifiers in pancreatic β-cell maturation and function. In a new project, funded by the Novo Nordisk Foundation, we are following up on these findings.
As a PhD fellow on this project, you will be working closely with a postdoc spearheading this project. You will apply a broad range of functional genomics, cellular and physiological technologies to determine the role of these epigenetic modifiers in β-cell maturation, in vivo as well as in vitro. Your work will be a combination of both experimental and computational approaches to address the key questions of the project.
The Mandrup Group
The Mandrup Group has a long-standing interest in understanding the molecular crosstalk between transcriptional regulation and metabolism in adipocytes and pancreatic β-cells and to understand the molecular basis for the plasticity of cells in the adipose tissue and endocrine pancreas. We also have a long-time interest in the transcriptional network regulating lineage determination and differentiation of adipocyte progenitors. Our laboratory combines genome-wide studies of factor binding, epigenetic marks and chromatin structure with detailed molecular analyses of the crosstalk between transcriptional regulators. We run an inhouse sequencing platform including single cell sequencing and bioinformatic pipeline.
Susanne Mandrup is Director of ADIPOSIGN as well as the Center of Excellence in Functional Genomics and Tissue Plasticity, and she heads the Functional Genomics and Metabolism Research Unit.
The research unit currently hosts eight independent research groups focusing on various aspects of functional genomics as it pertains to the regulation of cellular differentiation and metabolism. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging, and transgenic mouse work. Strategic research alliances exist with the Odense University Hospital (OUH).
Qualifications/requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:
- A completed or ongoing Master’s degree in Life Science, preferably Molecular Biology, Biomedicine, or Computational Systems Biology.
- Experience with research in the field of cell biology, transcriptional regulation or NGS data analysis. Knowledge about pancreatic beta-cells is an advantage.
- Strong communication and collaborative skills and a desire to work in an interdisciplinary environment.
- Proficiency in spoken and written English.
We offer:
- A three-year PhD position in a highly stimulating, supportive, international, and interdisciplinary research environment.
- Enrolment in the PhD school of Biochemistry and Molecular Biology, which allows the candidate to tailor a flexible individualized course programme.
- Training in a wide range of skills including research management, communication, networking, presentations, writing of manuscripts, teaching etc.
- Research exchange to collaborating institution, depending on the interest of the PhD student.
- Mentoring and career development.
- Access to state-of-the-art equipment, facilities, and infrastructure.
- Opportunity to interact with an extensive network of national and international collaborators.
- A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.).
- Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.
For further information please contact Professor Susanne Mandrup ([email protected]).
Application, salary etc.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be in English and made in the form of a Declaration of Interest including the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box "Application form")
• Detailed CV, including personal contact information
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades
• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail: [email protected] mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Shortlisting may be used in the assessment process.
Further information about the PhD-study can be found at the homepage of the University.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 27.6.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
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