Postdoctoral Position in RNA Biology with Focus on Disease-associated Mutations in the RNA-binding Proteins RBM10 and...
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Odense M
The RNA splicing and Disease group at the Section for Translational Biology, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding postdoctoral candidates. The position is available from 1 January 2024, or as soon as possible thereafter and the employment will run for up to two years. Application deadline: 10 November 2023.Research projectTo investigate a new disease mechanism where inherited mutations in the RNA binding domains of the splicing regulatory proteins RBM10 and RBM12 lead to new clinical phenotypes. It is hypothesized that missense mutations may alter the conformation and structure of RBM10/RBM12 RNA binding domains thereby changing their RNA recognition and target binding.
The postdoctoral candidate will investigate in molecular detail, employing advanced techniques (RNA-seq of patient samples, CRISPR/Cas genome editing, eCLIP, in-vitro RNA binding, SSOs etc.) how mutations in these RNA binding proteins cause splicing changes in target genes, leading to altered functions and shifts in gene regulatory networks important in development and cancer.
The project will provide a paradigm for future studies of structure function relationships in other RNA Binding Motif proteins and contribute important knowledge on the molecular mechanisms involved when mutations in these functional domains lead to dramatically different phenotypes.
The Splicing and Disease GroupThe group leader, Brage Storstein Andresen, PhD, FRCPath, is professor and head of the section for Translational Biology. The research group has for years focused on regulation of normal and aberrant alternative pre-mRNA splicing. We employ state of the art techniques to study the molecular pathology of aberrant splicing in human disease and the basic biology of RNA binding proteins. We develop methods for modulation of splicing using splice switching oligonucleotides (SSOs) to treat Human disease. We also develop software to predict the effect of sequence changes on binding of splicing regulatory proteins to RNA and to pinpoint parts of the transcriptome vulnerable to splicing mutations.
Research environmentThe research group is part of an international, ambitious, highly dynamic, and well-equipped working environment. The section and the department have state-of-the-art facilities for next generation sequencing, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. The project is carried out in collaboration with Odense University Hospital (OUH) and international collaborators.
Qualifications/requirements We are looking for highly motivated, dedicated, and ambitious scientists with:
We offer
For further information please contact Professor, Head of Section, Brage Storstein Andresen, [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
The postdoctoral candidate will investigate in molecular detail, employing advanced techniques (RNA-seq of patient samples, CRISPR/Cas genome editing, eCLIP, in-vitro RNA binding, SSOs etc.) how mutations in these RNA binding proteins cause splicing changes in target genes, leading to altered functions and shifts in gene regulatory networks important in development and cancer.
The project will provide a paradigm for future studies of structure function relationships in other RNA Binding Motif proteins and contribute important knowledge on the molecular mechanisms involved when mutations in these functional domains lead to dramatically different phenotypes.
The Splicing and Disease GroupThe group leader, Brage Storstein Andresen, PhD, FRCPath, is professor and head of the section for Translational Biology. The research group has for years focused on regulation of normal and aberrant alternative pre-mRNA splicing. We employ state of the art techniques to study the molecular pathology of aberrant splicing in human disease and the basic biology of RNA binding proteins. We develop methods for modulation of splicing using splice switching oligonucleotides (SSOs) to treat Human disease. We also develop software to predict the effect of sequence changes on binding of splicing regulatory proteins to RNA and to pinpoint parts of the transcriptome vulnerable to splicing mutations.
Research environmentThe research group is part of an international, ambitious, highly dynamic, and well-equipped working environment. The section and the department have state-of-the-art facilities for next generation sequencing, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. The project is carried out in collaboration with Odense University Hospital (OUH) and international collaborators.
Qualifications/requirements We are looking for highly motivated, dedicated, and ambitious scientists with:
- A PhD degree in Life Science, preferably Molecular Biology or Biomedicine.
- Documented expertise in RNA biology and RNA-seq data analysis is an advantage.
- Ideally at least one first author publication in a relevant journal.
- Strong communication and collaborative skills.
- Proficiency in spoken and written English.
We offer
- A two-year postdoc position in a stimulating and supportive, international research environment.
- Access to state-of-the-art equipment, facilities, and infrastructure.
- Mentoring and career development.
- Opportunity to interact with an extensive network of national and international collaborators.
- A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.).
- Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.
For further information please contact Professor, Head of Section, Brage Storstein Andresen, [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 5.10.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
- Fredag den 10. november 2023
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